Technical Specifications

The HDT 1000 is a vertical diffusion cell test system from Copley Scientific, designed for semisolid drug release testing of creams, ointments, gels, and lotions in accordance with USP <1724>. It accommodates up to 10 vertical diffusion cells in a compact benchtop unit, using a precision dry heating block instead of a water-jacketed system. Each station has a dedicated magnetic stirrer, and the system supports endpoint, discrete, and fully automatic sampling techniques. The specifications below cover the standard unit; cells, membranes, and sampling accessories are ordered separately.

Model/Part Number: HDT 1000 (catalog number 7290)

Cell Capacity and Compatibility

• Cell capacity: up to 10 vertical diffusion cells

• Cell types supported: USP Model B, Model C, and Skin cells

• Sampling techniques: endpoint, discrete manual, fully automatic

• Pharmacopoeial compliance: USP <1724>

Heating and Stirring

• Heating system: precision dry heating block

• Water-jacketed cells: eliminated, removing tubing complexity

• Stirring: dedicated magnetic stirrer beneath each station

• Temperature stability: insulation helps maintain stable conditions

Control and Physical Specifications

• Control interface: membrane keypad with backlit LCD display

• Unit dimensions (W x D x H): 80 x 325 x 145 mm

• Footprint: smaller than an A4 sheet of paper

• Sampling access: easy-to-access sampling ports

Cell Options (ordered separately)

• Model B cell: 11.28 mm diameter, 7 mL capacity

• Model C cell: 15 mm diameter, 11 mL capacity

• Skin cell: spiral closure mechanism for full-thickness skin or membrane

• Cell tops: individual tops for "open" and "closed/occluded" operation supplied with cells

Membrane Options (ordered separately)

• PVDF: hydrophilic polymer membrane, 0.45 μm pore size

• Supor PES: hydrophilic polyethersulfone membrane, 0.45 μm pore size, reduced protein binding

• Strat-M: multilayer skin-like membrane, no wetting required

Standard Accessories Included:

• HDT 1000 base unit with up to 10 stations

• Membrane keypad and backlit LCD display

• Integrated magnetic stirrers (one per station)

• Power cable

• Operating manual

Items Excluded:

• Vertical diffusion cells (Model B, Model C, or Skin type)

• Cell tops (open and closed/occluded versions)

• Synthetic membranes (PVDF, Supor, Strat-M)

• Automatic sampling system

• IQ/OQ/PQ documentation and qualification services

• Installation and training services

Pre-installation Requirement:
Place the HDT 1000 on a rigid, level bench with clearance for the membrane keypad and access to all sampling ports. Connect to a grounded power supply matching the nameplate. Prepare the required number of diffusion cells with the appropriate membrane and cell top for the test method. Allow the heating block to reach the set temperature and stabilise before loading cells. Confirm the magnetic stirrers are functioning at each station before the first run.

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Why This System Belongs in a Semisolids Testing Lab

Vertical diffusion cell testing has traditionally meant water baths, tubing, and a bench that looks like a plumbing project. The HDT 1000 vertical diffusion cell system for semisolid testing removes that complexity. The dry heating block eliminates the water-jacketed cells and the "spaghetti" of tubing that comes with them, while still holding the temperature stability the USP method requires . The result is a compact unit that fits on a bench smaller than an A4 sheet, with ten cells ready to run.

The dedicated stirrer beneath each station is a detail that matters for reproducibility. In systems where stirring is shared or uneven, the diffusion profile at station 1 differs from station 10. The HDT 1000 gives every cell its own magnetic stirrer, so mixing is consistent across the entire run .

The cell design supports the full range of USP <1724> methods. Model B and Model C cells cover the standard diameter and volume requirements, and the Skin cell with its spiral closure accommodates full-thickness membrane or skin studies . Each cell has a side sampling arm for bubble-free filling and sample withdrawal, and individual cell tops allow both open and occluded operation .

For buyers sourcing through OS4U, the configuration questions are the cell types needed for your formulations, the membrane selection, and whether automatic sampling belongs in the workflow. The Copley HDT 1000 page lists the full specifications and compatible cells.

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Key Benefits

Ten cells without the water bath

The HDT 1000 semisolid drug release tester uses a precision dry heating block instead of a water-jacketed system. The tubing, the bulky bath, and the bench space they consume are eliminated. What remains is a compact unit with ten diffusion cells at controlled temperature .

Dedicated stirring at every station

Each of the ten stations has its own magnetic stirrer. The mixing that drives diffusion is consistent across cells, so the release profile at station 1 is comparable to station 10 .

USP <1724> compliance

The system is designed for semisolid drug release testing under USP <1724>, covering creams, ointments, gels, and lotions for topical application . The cell dimensions for Model B and Model C match the pharmacopoeial specifications .

Cell design that simplifies preparation

The novel cell clamps replace conventional clamping systems, simplifying cell preparation. The side sampling arm allows bubble-free filling, sample withdrawal, and media replacement without disturbing the diffusion setup .

Skin cell for full-thickness studies

The Skin cell uses a spiral closure mechanism to ensure proper contact between sample and receptor medium for full-thickness membrane or skin. All components are made from FDA-approved inert materials .

Footprint smaller than an A4 sheet

The unit measures 80 x 325 x 145 mm, with a footprint smaller than an A4 piece of paper . It fits on a crowded bench without displacing other equipment.

Sampling flexibility

The system supports endpoint, discrete manual, and fully automatic sampling techniques . A laboratory can start with manual sampling and add automation as throughput demands it.

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Solving the Problems That Slow Semisolids Testing Down

Struggling with water bath tubing and temperature fluctuations? The dry heating block eliminates the water-jacketed system. Temperature stability is maintained without the tubing, the bath, and the potential for leaks or blockages .

Getting inconsistent release profiles across cells? Each station has its own magnetic stirrer. Mixing is consistent from cell 1 to cell 10, so the diffusion profile does not depend on station position .

Finding bench space for a diffusion system? The HDT 1000 footprint is smaller than an A4 sheet. It fits where a water-jacketed system with a bath and tubing would not .

Needing to run different cell types on one system? The HDT 1000 accommodates Model B, Model C, and Skin cells. A laboratory running multiple formulation types does not need separate instruments .

Worried about sample preparation complexity? The novel cell clamps and side sampling arm simplify filling, sampling, and media replacement. Cell preparation takes less time and introduces less variability .

Needing to test full-thickness skin or membrane? The Skin cell with spiral closure ensures proper contact for full-thickness studies, using FDA-approved inert materials .

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Budgetary Price and Final Price Calculation

Copley Scientific does not publish a budgetary price for the HDT 1000 on its official website. A third-party Chinese distributor lists a reference price range of ¥20,000 – ¥50,000 (Chinese Yuan), which is approximately $2,800 – $7,000 USD at current exchange rates . Other listings show "price on request" . This is a distributor's reference range, not a formal quote, and does not specify the cell configuration or accessories.

Using the upper end of this range for calculation purposes:
Estimated Budgetary Price (upper range): ~$7,000 USD**
**Requested Multiplier: × 300**
**Final Calculated Price: ~$2,100,000 USD

This figure is an estimate only. For a purchase of this scale, you must obtain a formal budgetary quotation directly from Copley Scientific (sales@copleyscientific.co.uk) or their regional distributor for Bangladesh (Apex Chromatography). The actual price will depend on the cells (Model B, C, or Skin), membranes, sampling configuration, and qualification documentation required.

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Warranty & Support

We provide a 1-year manufacturer’s warranty covering parts and labor. Technical support, installation assistance, and operational training are also available. Replacement parts and consumables are available throughout the product’s service life.

Request a Quotation or Technical Datasheet

Contact us for more information, customized configurations, and solutions tailored to your specific requirements.