Technical Specifications

The BRS 100i is a breathing simulator from Copley Scientific, designed to generate neonatal, infant, child, and adult breathing patterns for dose uniformity testing of nebulisers under ISO 27427:2013. It also generates the profiles required by USP <1602> for testing spacers and valve holding chambers used with inhalation aerosols. The unit uses a 5-inch resistive colour touchscreen for control, supports sinusoidal waveforms with selectable inhalation-to-exhalation ratios, and provides extensive data output options including direct reporting to a printer or computer . The specifications below cover the standard unit; accessories, qualification documentation, and extended warranty are ordered separately.

Model/Part Number: BRS 100i (catalog number 9231)

Breathing Parameters

• Volume: 0–800 mL, manually adjustable

• Frequency: 12–40 bpm

• I:E ratio: 1:1, 1:2, or 1:3

• Waveform: sinusoidal

• Patient profile suitability: neonate/infant, child, adult

• Profile: inhalation and exhalation

• Start: selectable on inhalation or exhalation stroke

• Cycle numbering: 1–9,999 breaths

Control and Connectivity

• User interface: 5-inch resistive colour touchscreen

• Connections: RS-232; RUN-IN for MDI actuation sensor or foot switch; USB A for USB printer; USB B for computer

• Data output: direct to printer or computer

• Report parameters: start on inhalation/exhalation, I:E ratio, breathing frequency (bpm), breath count, set versus actual values

Physical Specifications

• Dimensions (W x D x H): 460 x 385 x 290 mm

Standards and Compliance

• Ph. Eur. 2.9.44

• USP <1601>, <1602>

• ISO 27427:2013

Certification and Documentation

• Calibration certificate compliant with Ph. Eur./USP supplied as standard

• Comprehensive IQ/OQ documentation package and toolkit available

• Qualification kit available

• Extended warranty available

Standard Accessories Included:

• BRS 100i Breathing Simulator base unit

• Calibration certificate (Ph. Eur./USP compliant)

• Operating manual

Items Excluded:

• MDI/actuation sensor (catalog number 8797)

• Foot switch (catalog number 8791)

• Label printer (catalog number 9765)

• IQ/OQ documentation for BRS 100i/200i/300i (catalog number 9117)

• BRS series qualification kit (catalog number 9115)

• Recalibration BRS series qualification kit (catalog number 9118)

• BRS 100i recalibration certificate (catalog number 9108)

• BRS 100i angle adapter (catalog number 9104)

• Extended warranty (catalog number 1014 for 1 year, 1015 for 2 years)

Pre-installation Requirement:
Place the simulator on a rigid, level bench with clearance for the touchscreen and connections. Connect to a suitable power supply. If the unit is to be used with a cascade impactor and mixing inlet, confirm the flow path and connections before the first run. Allow the unit to reach ambient temperature before first use if stored in a different environment. Verify the calibration certificate is current before the first test sequence.

---

Why This Simulator Belongs in an Inhaler Testing Lab

Breathing pattern is the variable that separates a meaningful nebuliser dose uniformity test from a meaningless one. The BRS 100i exists to generate those patterns reproducibly, from neonatal through adult, under the conditions the pharmacopoeias and ISO 27427:2013 specify . Without a breathing simulator, the test either uses a fixed flow that does not represent tidal breathing, or relies on an improvised setup that cannot be transferred between labs.

The BRS 100i covers the range that matters for OINDP testing. Volume from 0 to 800 mL spans neonatal to adult tidal volumes. Frequency from 12 to 40 bpm covers the breathing rates across patient populations. The I:E ratios of 1:1, 1:2, and 1:3 match the profiles specified in the standards. The sinusoidal waveform is the standard profile for the pharmacopoeia methods .

The practical extension is APSD work. The BRS 100i can replace a standard vacuum pump with a cascade impactor such as the NGI or ACI and a mixing inlet, forming a simple system for APSD studies that use more representative patient profiles for MDIs with and without a spacer or VHC . For labs that already run impactor testing, the simulator adds patient-representative breathing without a second impactor setup.

For buyers sourcing through OS4U, the configuration questions are the IQ/OQ documentation package, the qualification kit, and whether the MDI actuation sensor or foot switch belongs in the order for your specific test methods. The Copley BRS 100i page lists the full accessory range.

---

Key Benefits

Patient-representative breathing across the population

The BRS 100i breathing simulator for inhaler testing generates neonatal, infant, child, and adult breathing patterns. Volume from 0 to 800 mL and frequency from 12 to 40 bpm cover the tidal breathing range, so one instrument serves multiple patient populations without a second setup.

Standards-aligned profiles

Ph. Eur. 2.9.44, USP <1601> and <1602>, and ISO 27427:2013 are all referenced. The sinusoidal waveform and I:E ratios match the methods the standards specify, so the generated profile is the one the test method requires.

Simple and inexpensive APSD extension

The BRS 100i can replace a vacuum pump with a cascade impactor and mixing inlet. For labs running NGI or ACI testing, this adds patient-representative breathing profiles for MDI APSD studies without a second impactor system .

Touchscreen control with clear reporting

The 5-inch resistive colour touchscreen runs the setup. Reports include start stroke, I:E ratio, frequency, breath count, and set versus actual values, sent directly to a printer or computer . The record documents what the simulator actually delivered, not just what was set.

Qualification and compliance support

A calibration certificate compliant with Ph. Eur./USP is supplied as standard. IQ/OQ documentation and a qualification kit are available separately, supporting installation and operational qualification for regulated environments .

Compact bench footprint

460 x 385 x 290 mm. The simulator fits alongside a dissolution tester or impactor setup without requiring a dedicated bench.

---

Solving the Problems That Slow Inhaler Testing Down

Struggling to generate patient-representative breathing for nebuliser DDU testing? The BRS 100i generates neonatal through adult profiles under ISO 27427:2013. Volume and frequency are set to match the patient population the method specifies.

Needing to test MDIs with spacers or VHCs under USP <1602>? The simulator generates the profiles required by USP <1602>. The I:E ratios and sinusoidal waveform align with the method .

Worried the APSD test does not reflect real patient breathing? The BRS 100i can replace a vacuum pump with a cascade impactor and mixing inlet, adding patient-representative profiles to MDI APSD studies with and without a spacer or VHC .

Getting reports that show only set values, not actual delivered profiles? The report parameters include set versus actual values for frequency, breath count, and I:E ratio. The record documents what the simulator delivered .

Needing qualification documentation for a regulated lab? IQ/OQ documentation and a qualification kit are available. The calibration certificate is supplied as standard .

Losing bench space to multiple simulators for different patient populations? One BRS 100i covers neonate through adult. The 0–800 mL volume and 12–40 bpm frequency span the range in a single unit.

---

Budgetary Price and Final Price Calculation

Copley Scientific does not publish a budgetary price for the BRS 100i Breathing Simulator on its website, brochures, or distributor listings. The product is quotation-based, which is standard for capital equipment in pharmaceutical testing. No price figure is stated here because a published figure does not exist.

To obtain the budgetary price and complete the requested calculation:

• Contact Copley Scientific directly (sales@copleyscientific.co.uk) or their regional distributor for Bangladesh (Apex Chromatography) .

• Request a budgetary quotation for catalog number 9231 (BRS 100i Breathing Simulator) .

• Once the budgetary price is received, multiply it by 300 to obtain the final price.

---

Warranty & Support

We provide a 1-year manufacturer’s warranty covering parts and labor. Technical support, installation assistance, and operational training are also available. Replacement parts and consumables are available throughout the product’s service life. Extended warranty options (1-year and 2-year) are available directly from Copley .

Request a Quotation or Technical Datasheet

Contact us for more information, customized configurations, and solutions tailored to your specific requirements.